Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

135
The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
135
Multiple Allele Traits01:49

Multiple Allele Traits

32.5K
The Concept of Multiple Allelism
32.5K
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

5.8K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
5.8K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

156
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
156
Genetic Variation01:25

Genetic Variation

1.6K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.6K
Genetic Lingo01:11

Genetic Lingo

84.3K
Overview
84.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of an education intervention to support genomics research participation: a community-based pre-post study among participants under-represented in diabetes genomics research.

BMJ open·2026
Same author

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Heterogeneity Analysis of Associations Involving the Large-Scale Online MindCrowd Survey Memory Test.

Gerontology·2025
Same author

A mRNA vaccine encoding for a 60-mer Nipah virus G glycoprotein nanoparticle elicits a robust neutralizing antibodies response against the Nipah virus.

Vaccine·2025
Same author

Genetic variants influencing liver fat in normal-weight individuals of European ancestry.

JHEP reports : innovation in hepatology·2025
Same author

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Apr 26, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K

Admixture and clinical phenotypic variation.

Laura H Goetz1, Liliana Uribe-Bruce, Danjuma Quarless

  • 1The Scripps Translational Science Institute, La Jolla, Calif., USA.

Human Heredity
|July 26, 2014
PubMed
Summary
This summary is machine-generated.

Human population genetic differentiation, driven by migration and isolation, influences observable traits. Admixture between distinct groups can lead to varying phenotypic expressions, impacting clinical relevance and gene mapping.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.4K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

8.9K

Related Experiment Videos

Last Updated: Apr 26, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.4K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

8.9K

Area of Science:

  • Population Genetics
  • Human Evolution
  • Genomic Medicine

Background:

  • Human populations display genetic differentiation due to factors like migration, isolation, drift, and selection.
  • Long-term isolation can lead to distinct gene pools and observable phenotypic differences.
  • Admixture between populations with differing genetic variants results in varied phenotypic expression based on inherited ancestry.

Purpose of the Study:

  • To review studies associating admixture (ancestry) with clinically relevant phenotypes.
  • To explore the implications of these associations for gene mapping and clinical epidemiology.
  • To consider future research directions for phenotypic variation in admixed and ancestrally diverse individuals.

Main Methods:

  • Literature review of studies examining the relationship between genetic admixture and phenotypes.
  • Analysis of evidence for associations between ancestry and phenotypic variation.
  • Consideration of implications for genetic research and clinical practice.

Main Results:

  • Substantial literature supports associations between degree of admixture and phenotypic variation in various admixed populations.
  • Evidence for these associations is not universally confirmatory across all studies.
  • Admixture's influence on phenotype is linked to the frequency of ancestral causative variants.

Conclusions:

  • Genetic admixture significantly influences phenotypic variation, with clinical relevance.
  • Understanding admixture is crucial for accurate gene mapping and epidemiological studies.
  • Further research is needed to fully elucidate phenotypic differences in diverse ancestral groups.