Related Experiment Video
Updated: Apr 26, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance?
Ashleigh Allen1, Kamraan Gill1, Daniela Hoehn1
1Department of Pathology and Cell Biology, Division of Hematopathology, Columbia University Medical Center, New York, NY, USA.
Abstract:
C-myc protein expression has been studied in mature B-cell lymphomas and overexpression has been associated with poor prognosis. We sought to determine the prognostic significance of c-myc protein expression in B-ALL. We found ≥ 20% c-myc expression to predict risk of persistent disease in all age groups (odds ratio 7.487, p=0.013). There was no statistically significant association between c-myc expression and risk of relapse or death in our study. Routine c-myc immunostaining may help identify higher risk patients and guide management of B-ALL. Additional studies are needed to further determine the molecular mechanisms and role of c-myc expression in B-ALL.
Related Concept Videos
Abnormal Proliferation
Induced Pluripotent Stem Cells
Somatic...
Differentiation of Common Myeloid Progenitor Cells
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Master Transcription Regulators

