Related Experiment Video

Updated: Apr 26, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

10.3K

MicroRNA and signaling pathways in gastric cancer

Z Zhang1, Z Li1, Y Li2

  • 1Department of Oncological Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Cancer Gene Therapy
|July 26, 2014
PubMed

Insights

MicroRNAs (miRNAs) are key in gastric cancer, acting as oncogenes or tumor suppressors. This study clarifies their complex roles and regulatory networks, offering insights into patient outcomes and potential treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) regulate gene expression, influencing cellular processes.
  • Their roles in cancer, including gastric cancer, are complex, acting as oncogenes or tumor suppressors.
  • miRNAs interact with canonical signaling pathways, further complicating their function in disease.

Purpose of the Study:

  • To elucidate the pathogenic mechanisms of gastric cancer linked to miRNA expression.
  • To map the regulatory network of miRNA expression in gastric cancer progression.
  • To correlate miRNA expression with patient outcomes in gastric cancer.

Main Methods:

  • Systematic review of recent high-quality studies on miRNA expression in gastric cancer.
  • Analysis of miRNA regulatory networks and their involvement in signaling pathways.
  • Correlation analysis between miRNA expression levels and patient prognosis.

Main Results:

  • Identified specific miRNAs with oncogenic or tumor-suppressive roles in gastric cancer.
  • Detailed the intricate regulatory network governing miRNA expression during gastric cancer development.
  • Established significant correlations between certain miRNA expression patterns and patient survival rates.

Conclusions:

  • miRNA dysregulation is a critical factor in gastric cancer pathogenesis.
  • Understanding miRNA-pathway interactions provides a basis for novel therapeutic strategies.
  • Targeting specific miRNAs holds promise for improving gastric cancer treatment outcomes.

More Related Videos

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.1K
Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.5K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
20.9K
MicroRNAs01:22

MicroRNAs

9.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
4.6K