Related Experiment Video

Updated: Apr 26, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

19.2K

Low treatment rates in patients meeting guideline criteria in diverse practice settings

Lily H Kim1, Vincent G Nguyen, Huy N Trinh

  • 1Division of Gastroenterology and Hepatology, Stanford University Medical Center, 750 Welch Road, Suite 210, Palo Alto, CA, 94304, USA, lilyhkim@stanford.edu.

Digestive Diseases and Sciences
|July 26, 2014
PubMed

Insights

Treatment rates for chronic hepatitis B (CHB) vary by care setting. Hepatology clinics offer higher CHB treatment rates than primary care, underscoring the need for improved patient and provider education.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Primary Care Medicine

Background:

  • Limited data exists on antiviral therapy usage and chronic hepatitis B (CHB) guideline adherence across diverse clinical settings.
  • Evaluating treatment eligibility and initiation rates is crucial for optimizing CHB management.

Purpose of the Study:

  • To assess the proportion of treatment-eligible CHB patients at 6-month follow-up.
  • To determine the treatment rate among eligible CHB patients at 12-month follow-up in primary care, gastroenterology, and hepatology settings.

Main Methods:

  • Retrospective cohort study of 1,976 treatment-naïve CHB patients.
  • Patients categorized into primary care physician (PCP), gastroenterology (GI), and hepatology groups.
  • Treatment eligibility assessed using US Panel 2008 and AASLD 2009 guidelines.

Main Results:

  • Hepatology and GI groups showed similar eligibility rates (US Panel: 53-54%; AASLD: 24-25%).
  • Treatment rates were significantly higher in hepatology vs. GI (US Panel: 59% vs. 45%).
  • PCP group had the lowest eligibility and treatment rates; common non-treatment reasons included perceived normal ALT and patient preference.

Conclusions:

  • Less than half of eligible CHB patients in primary care received treatment.
  • Community GI and university liver clinics treated approximately 50-66% of eligible patients.
  • Enhanced patient and provider education on CHB treatment benefits and updated ALT guidelines is recommended.
Abstract

Related Concept Videos

Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
2.3K
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
922
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
387
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
230