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New introductions of enterovirus 71 subgenogroup C4 strains, France, 2012

Isabelle Schuffenecker, Cécile Henquell, Audrey Mirand

    Emerging Infectious Diseases
    |July 26, 2014
    PubMed

    Insights

    Human enterovirus 71 (EV-A71) C4 strains were found in French children in 2012. This suggests new EV-A71 introductions into Europe, highlighting the need for ongoing surveillance.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Public Health

    Background:

    • Human enterovirus 71 (EV-A71) is a significant pathogen causing neurological diseases.
    • Neonatal fever and meningitis are serious conditions that can be caused by viral infections.

    Observation:

    • In 2012, four children in France were hospitalized with neonatal fever or meningitis.
    • EV-A71 subgenogroup C4 strains were identified in these pediatric cases.

    Findings:

    • Phylogenetic analysis revealed novel and independent introductions of EV-A71 into France.
    • These introductions were likely originating from China.
    • Evidence suggests the circulation of EV-A71 C4 strains across France.

    Implications:

    • The findings underscore the importance of monitoring EV-A71 infections in European populations.
    • Early detection and surveillance are crucial for managing potential outbreaks.
    • Understanding viral introduction pathways aids in public health preparedness.

    Keywords:
    FrancePicornaviridaeenterovirus 71enterovirus species Afoot and mouth diseasehandherpanginahumansmeningitismeningoencephalitisneonatal feverphylogenetic analysesrhomboencephalitissubgenogroup C4viruses

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