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Updated: Apr 26, 2026

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
Published on: August 12, 2019
Pharmacological modulation of monocytes and macrophages
Alberto Mantovani1, Annunciata Vecchi2, Paola Allavena2
1Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano, Italy; Department of Biotechnology and Translational Medicine, University of Milan, 20089 Rozzano, Italy.
Abstract:
Mononuclear phagocytes are major players in diverse pathological conditions which include chronic inflammatory diseases, infection, autoimmunity, atherosclerosis, metabolic disorders, and cancer. Plasticity is a fundamental property of cells of the monocyte-macrophage lineage and a variety of modulators profoundly affect monocytes and macrophages. Tumor-associated macrophages (TAMs) provide a paradigm for macrophage plasticity and anticancer therapeutic modalities (chemotherapy, radiotherapy, and immunotherapy) profoundly affect their function. The development of innovative strategies targeting cells of the monocyte-macrophage lineage may pave the way to innovative therapies for a wide range of diseases.
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