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The nutritional status and factors contributing to malnutrition in children with chronic pancreatitis
E Kolodziejczyk1, K Wejnarska1, M Dadalski1
1Department of Gastroenterology, Hepatology and Feeding Disorders, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.
Insights
Malnutrition affects 25% of children with chronic pancreatitis (CP). Later age at CP onset is linked to increased malnutrition risk in these pediatric patients.
Area of Science:
- Pediatric Gastroenterology
- Nutritional Science
- Pancreatic Diseases
Background:
- Chronic pancreatitis (CP) is a debilitating condition in children.
- Malnutrition is a significant concern in pediatric CP.
- Understanding malnutrition prevalence and risk factors is crucial for management.
Purpose of the Study:
- To determine the prevalence of malnutrition in children with CP.
- To investigate the relationship between CP etiology, clinical features, and malnutrition severity.
Main Methods:
- Study included 208 children with CP (1988-2012).
- Malnutrition severity assessed using Cole's ratios.
- Analysis included etiological factors, clinical characteristics, and discriminant analysis for malnutrition predictors.
Main Results:
- 25% of children with CP exhibited malnutrition (17.3% moderate, 0.96% severe).
- No significant difference in malnutrition prevalence across different CP etiological factors.
- Later age at CP onset was a significant predictor of malnutrition.
Conclusions:
- A substantial proportion of children with CP experience malnutrition.
- Delayed onset of CP is associated with a higher risk of developing malnutrition.
Background/Objectives:
The present study was undertaken to determine the prevalence of malnutrition among children with chronic pancreatitis (CP). Furthermore, we aimed to evaluate the relationship between etiological factors of CP, its clinical characteristics, and the severity of malnutrition.
Methods:
The study included 208 children with CP (113 girls and 95 boys; mean age: 10.8 years, range: 1.6-18 years), hospitalized at our center between 1988 and 2012. The severity of malnutrition was graded on the basis of Cole's ratios, and its prevalence was analyzed according to the etiological factors of pancreatitis. Moreover, the analysis of discrimination was performed to identify the factors contributing to malnutrition among the following variables: age at CP onset, duration of CP, number of CP exacerbations, the number of ERCPs performed, the grade of pancreatic damage documented on imaging, co-occurrence of diabetes, and the results of 72-h fecal fat quantification.
Results:
We documented features of malnutrition in 52 (25%) children with CP, including 36 (17.3%) patients with moderate malnutrition, and 2 (0.96%) with severe malnutrition. There was no significant difference in the prevalence of malnutrition between groups of patients with various etiological factors of chronic pancreatitis. The age at CP onset showed the best discrimination ability of malnourished patients: the mean age at disease onset in a subgroup of malnourished children was significantly higher than in children with Cole's index >85%.
Conclusions:
A considerable percentage of children with CP can suffer from clinically significant malnutrition. Later age at CP onset predisposes to development of malnutrition.
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