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Related Experiment Video

Updated: Apr 26, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

A novel bio-safe phase separation process for preparing open-pore biodegradable polycaprolactone microparticles.

Aurelio Salerno¹, Concepción Domingo¹

¹Institute of Materials Science of Barcelona (ICMAB-CSIC), Campus de la UAB s/n, Bellaterra, 08193, Spain.

Materials Science & Engineering. C, Materials for Biological Applications

|July 27, 2014

Summary

Researchers developed a bio-safe method to create porous biodegradable microparticles using ethyl lactate and polycaprolactone. These microparticles are suitable for drug delivery and tissue engineering applications.

Keywords:

Biodegradable particles Ethyl lactate Phase separation Polycaprolactone Porosity

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

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Last Updated: Apr 26, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Open-pore biodegradable microparticles are essential for biomedical applications like drug delivery and tissue engineering.
Fabricating microparticles with controlled size and pore architecture using safe methods is critical to avoid cellular toxicity.
Current methods may involve toxic compounds, necessitating the development of bio-safe alternatives.

Purpose of the Study:

To develop a straightforward and bio-safe approach for fabricating porous biodegradable microparticles with controlled nanoscale features.
To utilize ethyl lactate as a non-toxic solvent for polycaprolactone (PCL) microparticle fabrication.
To engineer multi-scaled porous microparticles with improved characteristics for cell culture and tissue engineering.

Main Methods:

Fabrication of porous polycaprolactone microparticles using ethyl lactate as a non-toxic solvent via thermal induced phase separation.
Application of porogen leaching techniques in combination with thermal induced phase separation to create multi-scaled porous structures.
Characterization of microparticle thermal properties, morphology, crystalline structure, and textural properties.

Main Results:

Successful fabrication of open-pore biodegradable microparticles with controlled size distribution (150-250 μm) and specific surface area (3.5-7.9 m²/g).
Demonstration of a bio-safe approach avoiding toxic solvents and compounds.
Creation of multi-scaled porous microparticles with potentially enhanced characteristics for biomedical applications.

Conclusions:

The developed thermal induced phase separation method using ethyl lactate offers a bio-safe route for producing porous biodegradable microparticles.
The engineered microparticles exhibit controlled morphological and structural features suitable for advanced biomedical applications.
This approach holds promise for improved cell culture and tissue engineering scaffolds and drug delivery systems.