Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.7K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

27
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
27
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Dementia l: Introduction01:22

Dementia l: Introduction

29
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
29
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

19
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
19
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

20
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validity of Wearable Inertial Sensors for Postural Sway Analysis: A Systematic Review.

Diagnostics (Basel, Switzerland)·2026
Same author

Are T1-weighted and T2-weighted volumetric pipelines interchangeable methodologies for investigating amyotrophic lateral sclerosis pathology in vivo?

Brain research bulletin·2026
Same author

Characterizing progressive cortical thinning in multiple system atrophy: a longitudinal MRI study.

NPJ Parkinson's disease·2026
Same author

Nutritional Influences on the Brain in ADHD: Evidence from Neuroimaging Studies.

Neurology international·2026
Same author

Exploring the relationship between retinal damage and cognition in multiple sclerosis: a cross-sectional OCT-MRI study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Editorial: Diffusion-weighted imaging: advances and implementations in neurology.

Frontiers in neurology·2026

Related Experiment Video

Updated: Apr 26, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.2K

Functional overlap and divergence between ALS and bvFTD.

Francesca Trojsi1, Fabrizio Esposito2, Manuela de Stefano3

  • 1Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy; Magnetic Resonance Imaging Research Center of the Second University of Naples-Italian Foundation for Multiple Sclerosis, Second University of Naples, Naples, Italy.

Neurobiology of Aging
|July 27, 2014
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) and behavioral variant frontotemporal dementia (bvFTD) share brain connectivity changes. However, the default mode network shows distinct patterns in ALS versus bvFTD, suggesting different neurodegeneration stages.

Keywords:
Amyotrophic lateral sclerosisBehavioral variant frontotemporal dementiaConnectivityPathologic continuumRS-fMRI

More Related Videos

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

2.5K
Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
13:31

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

8.1K

Related Experiment Videos

Last Updated: Apr 26, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.2K
Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

2.5K
Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
13:31

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

8.1K

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Amyotrophic lateral sclerosis (ALS) and behavioral variant frontotemporal dementia (bvFTD) are neurodegenerative diseases with overlapping clinical, pathological, and genetic features.
  • Neuroimaging, particularly resting-state functional magnetic resonance imaging (RS-fMRI), offers a valuable tool for investigating shared and distinct brain network alterations in these conditions.

Purpose of the Study:

  • To investigate and compare functional brain network connectivity patterns in early-stage ALS and bvFTD patients relative to healthy controls.
  • To identify commonalities and divergences in brain network connectivity between ALS and bvFTD using RS-fMRI.

Main Methods:

  • Resting-state functional magnetic resonance imaging (RS-fMRI) was employed to assess brain functional connectivity.
  • The study included 15 patients with early-stage ALS, 15 patients with early-stage bvFTD, and 15 age-matched healthy controls.
  • Analysis focused on comparing connectivity patterns across sensorimotor, frontoparietal, salience, executive, and default mode networks.

Main Results:

  • Both ALS and bvFTD patient groups exhibited decreased functional connectivity in sensorimotor, right frontoparietal, salience, and executive networks compared to controls.
  • Distinct patterns of connectivity were observed within the default mode network (DMN).
  • bvFTD patients showed enhanced DMN connectivity in the posterior cingulate cortex, whereas ALS patients displayed suppressed connectivity in the same region.

Conclusions:

  • ALS and bvFTD share common RS-fMRI connectivity alterations, potentially reflecting diverse phenotypic expressions of an underlying neurodegenerative process.
  • Differences in DMN connectivity between ALS and bvFTD suggest distinct stages or pathways of neurodegeneration.
  • RS-fMRI is a sensitive technique for differentiating between these related neurodegenerative disorders.