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Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Regulation of Heart Rates01:31

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The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Apr 26, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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SIRT1 in cardiovascular aging.

Xin-Yuan Luo1, Shun-Lin Qu1, Zhi-Han Tang1

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City 421001, Hunan Province, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 27, 2014
PubMed
Summary

Aging accelerates cardiovascular disease (CVD). Sirtuin1 (SIRT1) shows promise in delaying aging and treating age-related CVD by reducing oxidative stress and inflammation, and promoting autophagy.

Keywords:
Anti-aging strategiesAutophagyCardiovascular agingInflammationOxidative stressSIRT1

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Last Updated: Apr 26, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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Area of Science:

  • Gerontology
  • Cardiovascular Science
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) is a major global health concern, with aging being the primary risk factor.
  • Interventions to delay aging are crucial for preventing age-related diseases.
  • Sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, is linked to lifespan extension and possesses protective effects against aging and CVD.

Purpose of the Study:

  • To review the role of SIRT1 in cardiovascular aging.
  • To elucidate the molecular mechanisms underlying SIRT1's beneficial effects.
  • To assess the therapeutic potential of SIRT1 in age-related cardiovascular conditions.

Main Methods:

  • Literature review of studies on SIRT1 and cardiovascular aging.
  • Analysis of molecular pathways involving SIRT1, including oxidative stress, inflammation, and autophagy.
  • Evaluation of evidence for SIRT1's role in age-related CVD.

Main Results:

  • SIRT1 activation inhibits oxidative stress and inflammation in the cardiovascular system.
  • SIRT1 promotes autophagy, a cellular degradation process vital for maintaining cellular health during aging.
  • Evidence suggests SIRT1 plays a protective role against atherosclerosis and other age-related cardiovascular issues.

Conclusions:

  • SIRT1 is a key regulator of cardiovascular aging.
  • Targeting SIRT1, through moderate up-regulation or activation, holds significant therapeutic potential for age-related CVD.
  • Further research into SIRT1 pathways could lead to novel anti-aging strategies for cardiovascular health.