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[Malignant mesothelioma risk factors: experience in the General Hospital of Mexico]
Alejandro Hernández-Solís1, Cyntia Garcia-Hernández2, Arturo Reding-Bernal3
1Servicio de Neumología y Cirugía de Tórax, Hospital General de México O.D. Secretaría de Salud, Mexico. drhernandezsolis@yahoo.com.mx;
Background:
Malignant mesothelioma is a neoplasm of bad prognosis, it is linked with asbestos contact, but there are cases without this antecedent.
Objective:
To investigate the relationship of asbestos exposition and other factors with malignant mesothelioma.
Methods:
Retrospective analysis of histologic confirmed cases of malignant mesothelioma, neoplasic familiar history, tobacco smoking, exposure to wood smoke and to asbestos, were annotated in a paired case/control study 1: 1-3 with logistic regression model to identify risk factors for OR.
Results:
61 cases of malignant mesothelioma were confirmed by histopathologic study, 41 male and 20 female. Mean age was 56 years ± 13 years; 56 cases (91.8%) correspond to epithelial malignant mesothelioma, three sarcomatous (4.9%) one desmoplastic and one biphasic. One in eight (13.1%) had exposure to asbestos. Model of logistic regression with four variables: history of familiar cancer, tobacco smoking, wood smoke and asbestos exposition, the the last one with an OR= 3.083 and p > 0.05. No other variables found to be a risk factor for malignant mesothelioma.
Conclusions:
Exposure to asbestos is a risk factor for malignant mesothelioma, which is confirmed in this study, however it is important to extend the investigation of other possible causal factors of this disease.