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Updated: Apr 26, 2026
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Published on: December 14, 2018
Analyzing gene function in adult long-term hematopoietic stem cells using the interferon inducible Mx1-Cre mouse
Kristbjorn Orri Gudmundsson1, Kevin Oakley, Yufen Han
1Department of Pediatrics, Uniformed Services University of the Health Sciences, Bridge Road, Bethesda, MD, 20814, USA, kristbjorn.gudmundsson.ctr@usuhs.edu.
Abstract:
Long-term hematopoietic stem cells (LT-HSCs) have the ability to self-renew and differentiate into all blood cell lineages. Understanding the genetic networks that regulate LT-HSC function in the adult bone marrow requires inducible gene targeting and bone marrow transplantations. In this chapter we describe the use of the inducible Mx1-Cre mouse model to delete genes in LT-HSCs and methodologies for examining the function of LT-HSCs following deletion.
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