Foxp3 expression in deep rectosigmoid endometriosis lesions and its association with chronic pelvic pain
Sergio Podgaec1, Denise Frediani Barbeiro2, Bárbara Yasmin Gueuvoghlanian-Silva3
1Department of Obstetrics and Gynecology, Faculty of Medicine, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255, Cerqueira César CEP 05403-000, Sao Paulo, Brazil; Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi CEP 05652-900, Sao Paulo, Brazil.
Abstract:
Endometriosis is a benign gynecological disease that is related to immune response alterations. T regulatory cells modulate immune response, and Foxp3 seems to be the best marker of these cells. This study evaluated Foxp3 mRNA expression in eutopic endometrium from women with endometriosis and healthy controls, and its expression in deep rectosigmoid endometriosis lesions, one of the more aggressive types of the disease. Foxp3 expression was higher in lesions than in eutopic endometrium in the two groups. Moreover, eutopic endometrium Foxp3 expression of women with endometriosis was associated with chronic pelvic pain and cyclic urinary pain.
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