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1-Deamino-8-D-arginine vasopressin lowers protein C activity in uremics
N A Aunsholt1, E B Schmidt, E Stoffersen
1Department of Medicine, Aalborg Hospital, Denmark.
Nephron
|January 1, 1989
Abstract:
The effect of 1-deamino-8-D-arginine vasopressin (DDAVP) on protein C was investigated in 10 uremics and 10 normal subjects. The protein C antigen was higher in the uremic patients than in the normal subjects. DDAVP had no influence on the level of protein C antigen. However, functional protein C in uremics was lower than in normals even before administration of DDAVP. Furthermore, there was a decrease in functional protein C in the uremics after administration of DDAVP. Further studies are needed to clarify the low functional protein C in uremics both before and during administration of DDAVP.