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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: an

Akihiko Machino1, Yoshihiko Kunisato2, Tomoya Matsumoto3

  • 1Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Journal of Affective Disorders
|July 28, 2014
PubMed
Abstract

Insights

Treatment-resistant depression (TRD) patients exhibit gray matter (GM) abnormalities. Rumination in TRD patients is linked to increased GM volume in the right superior temporal gyrus, offering insights into TRD

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Major depressive disorder (MDD) is associated with gray matter (GM) abnormalities.
  • Studies on GM abnormalities in treatment-resistant depression (TRD) show inconsistent results.
  • The relationship between rumination and GM abnormalities in TRD is not well understood.

Purpose of the Study:

  • To investigate GM differences between TRD patients and healthy controls.
  • To explore the correlation between rumination and GM volume in TRD patients.

Main Methods:

  • Structural MRI scans and voxel-based morphometry (VBM) were used.
  • 29 TRD patients and 29 healthy controls were analyzed.
  • A response style questionnaire assessed rumination levels.

Main Results:

  • TRD patients had smaller GM volumes in the left dorsal ACC, right ventral ACC, right superior frontal gyrus, right cerebellum (Crus I), and cerebellar vermis compared to controls.
  • These specific regions did not correlate with rumination.
  • Rumination positively correlated with GM volume in the right superior temporal gyrus in TRD patients.

Conclusions:

  • TRD patients exhibit distinct GM abnormalities compared to healthy individuals.
  • This study is the first to link rumination with specific GM volumes in TRD.
  • Findings enhance understanding of the neuroanatomical characteristics of TRD.
Keywords:
Gray matter volumeMagnetic resonance imagingRuminationTreatment-resistant depressionVoxel-based morphometry

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