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Decreased peroxidative potential in rat brain microsomal fractions during ageing
1Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Neuroscience Letters
|August 14, 1989
Abstract:
Rough and smooth microsomes of brain in senescent rats showed less sensitivity to ascorbate-, NADPH- and cumene hydroperoxide-induced peroxidative damage compared with those of young adults. The observed decrease in peroxidative potential in senescent rats seemed to be due to decrease in the substrate for peroxidation in the form of phospholipids and increase in the level of antioxidants such as reduced glutathione and superoxide dismutase.