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Opioid involvement in TRH-induced antinociception in the rat following intracerebral administration
V Reny-Palasse1, C Monier, R Rips
1INSERM, Paris, France.
Pain
|August 1, 1989
Abstract:
Thyrotropin-releasing hormone (TRH) has an antinociceptive action in the rat. Antinociception was observed using a thermal stimulus (tail-flick test) after TRH administration into lateral ventricle, nucleus raphe magnus, nucleus reticularis paragigantocellularis and amygdaloid nuclei. This effect was short-lived since it was completely abolished 60 min after intracerebroventricular administration. TRH may interact with the opioid systems as its antinociceptive effect was blocked by pretreatment with naloxone.