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Updated: Apr 26, 2026

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
Published on: August 12, 2025
Effects of Lys-Glu-Trp peptide on cell-cell interactions and vascular endothelium proliferation under normal
V V Malinin1, A O Durnova, V O Polyakova
1Tsitomed Biomedical Research-and-Production Complex, St. Petersburg, Russia.
Abstract:
The molecular mechanism of atherosclerosis is based on decreased expression of signal molecules connexin (Cx37 and Cx40), vascular endothelial growth factor (VEGF), and proliferative protein Ki-67, which characterize the processes of cell-cell interactions and proliferation of vascular endotheliocytes. Lys-Glu-Trp peptide in doses of 4 and 40 μg/ml promoted recovery of Cx37, Cx40, and VEGF expression in cultured endotheliocytes from the aorta of patients with atherosclerosis, which attests to vasoprotective effects of this agent.
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