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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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Related Experiment Video

Updated: Apr 26, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

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Genome-wide screening for DNA variants associated with reading and language traits.

A Gialluisi1, D F Newbury, E G Wilcutt

  • 1Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

Genes, Brain, and Behavior
|July 29, 2014
PubMed
Summary
This summary is machine-generated.

Researchers identified genetic variants influencing reading and language skills by analyzing large datasets. Novel associations were found near the FLNC and RBFOX2 genes, suggesting shared genetic underpinnings for these complex traits.

Keywords:
CLDRCGWASSLICdevelopmental dyslexialanguagemeta-analysispleiotropic variantsreadingreading disabilityspecific language impairment

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Area of Science:

  • Genetics
  • Neuroscience
  • Developmental Biology

Background:

  • Reading and language abilities are complex, heritable traits.
  • These abilities are thought to share common genetic influences.
  • Identifying shared genetic factors is crucial for understanding developmental disorders.

Purpose of the Study:

  • To identify pleiotropic genetic variants that influence both reading and language abilities.
  • To leverage large, well-characterized datasets for genome-wide association studies.
  • To investigate novel genetic loci associated with reading and language skills.

Main Methods:

  • Performed a genome-wide association scan (GWAS) meta-analysis on 1862 participants from three datasets.
  • Utilized quantitative measures of reading and language abilities, adjusting for performance IQ.
  • Conducted univariate association testing and validated findings in an independent sample of 6434 individuals.

Main Results:

  • Identified suggestive associations at SNPs rs59197085 (near CCDC136/FLNC) and rs5995177 (near RBFOX2).
  • Both identified SNPs demonstrated effects across multiple reading and language traits.
  • The CCDC136/FLNC locus showed association in an independent general population sample.

Conclusions:

  • Novel genetic variants near FLNC and RBFOX2 may influence both reading and language abilities.
  • These findings highlight potential shared genetic mechanisms underlying these traits.
  • The study contributes to ongoing international efforts to map genes for reading and language skills.