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Fructose mediated crosslinking of proteins
D J Walton1, J D McPherson, B H Shilton
1Department of Biochemistry, Queen's University, Kingston, Ontario, Canada.
Progress in Clinical and Biological Research
|January 1, 1989
Abstract:
10-20% of the hexose bound to human ocular lens proteins was found to be attached to epsilon-amino groups of lysyl residues via carbon 2. It was concluded that the proteins had undergone nonenzymatic reactions with endogenous fructose. This process may be important in some mammalian tissues, owing to the high crosslinking potential of fructose.