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Updated: Apr 26, 2026

A Within-Subject Experimental Design using an Object Location Task in Rats
Published on: May 6, 2021
Pragmatic design in randomized controlled trials
M Purgato1, C Barbui1, S Stroup2
1WHO Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Department of Public Health and Community Medicine, Section of Psychiatry,University of Verona,Verona,Italy.
Abstract:
At more than 10 years after the paper by Hotopf and colleagues regarding pragmatic trials in psychiatry, the field has evolved and is evolving further. There have been many developments in our understanding of what pragmatism really means, and excellent examples of truly pragmatic trials in psychiatry are currently available. Funders have helped encourage more emphasis on the need for such studies, but 'local' and trans-national regulations could help more. Consumers of the evidence should have a greater voice in generating the research agenda and, as this happens, the questions generated are more likely to be answered by a pragmatic approach to trials.
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