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Updated: Apr 26, 2026

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Delta-like homologue 1 and its role in the bone marrow niche and hematologic malignancies
Leonidas Benetatos1, Eleftheria Hatzimichael2
1Blood Bank, General Hospital of Preveza, Preveza, Greece.
Abstract:
Delta-like homologue 1 (DLK1) is an imprinted gene, that acts as a Notch pathway antagonist. It is deregulated in solid and blood cancers, conferring malignant cells a cancer stem cell-like phenotype. DLK1 is important for normal hematopoiesis and for bone marrow homeostasis, because it directly affects the differentiation of mesenchymal stem cells into the nonhematopoietic components. It is possible that the resulting abnormal biology of mesenchymal stem cells promotes leukemic blasts survival providing also a sanctuary against chemotherapeutic agents. In this review, the effects of DLK1 on mesenchymal stem cells and the bone marrow microenvironment with perspectives are discussed.
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