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Related Concept Videos

Drug Therapy01:28

Drug Therapy

443
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
443
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

387
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
387
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

392
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
392
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

597
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
597
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

379
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
379
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

699
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
699

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Related Experiment Video

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Multidisciplinary Approach to Obesity Management: A Case Report
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[Developing a tailored intervention: implementing recommendations for polypharmacy in multimorbid patients (PomP)].

Cornelia Jäger1, Joachim Szecsenyi1, Tobias Freund1

  • 1Universitätsklinikum Heidelberg, Abteilung Allgemeinmedizin und Versorgungsforschung, Heidelberg.

Zeitschrift Fur Evidenz, Fortbildung Und Qualitat Im Gesundheitswesen
|July 29, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a stepwise concept for developing tailored interventions (TI) to implement evidence-based practices in healthcare. The method aids researchers in designing effective TI for improving patient care, particularly for multimorbid patients on polypharmacy.

Keywords:
ImplementationImplementierungLeitlinienPolypharmakotherapieTailoringguidelineknowledge translationpolypharmacytailoring

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Area of Science:

  • Health Services Research
  • Implementation Science
  • Evidence-Based Practice

Background:

  • Implementation research focuses on translating evidence-based knowledge into practice.
  • Tailored interventions (TI) are a key strategy, addressing specific barriers and enablers.
  • A standardized methodological concept for TI development is currently lacking.

Purpose of the Study:

  • To introduce and describe a stepwise concept for developing tailored interventions (TI).
  • To illustrate the TI development process with original data from general practitioner (GP) settings.
  • To provide a framework for implementing evidence-based recommendations for multimorbid patients with polypharmacy.

Main Methods:

  • A stepwise approach was employed for TI development.
  • Key steps included problem analysis, determinant identification and prioritization, and strategy selection.
  • The process culminated in designing a complex intervention with a logic model.

Main Results:

  • The study outlines a structured, stepwise method for creating tailored interventions.
  • Original data illustrates each developmental stage, from problem analysis to intervention design.
  • The developed TI provides evidence-based treatment recommendations for multimorbid patients on polypharmacy in GP settings.

Conclusions:

  • The described stepwise tailoring strategy offers a practical framework for researchers.
  • This methodology can guide the design of effective tailored interventions in implementation science.
  • The approach supports the translation of evidence into improved clinical practice for complex patient populations.