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Related Concept Videos

Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
419
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

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Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
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Related Experiment Video

Updated: Apr 26, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Four-dimensional MRI of renal function in the developing mouse.

Luke Xie1, Ergys Subashi, Yi Qi

  • 1Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.

NMR in Biomedicine
|July 29, 2014
PubMed
Summary

This study used advanced MRI to track kidney development in mice, revealing age-related changes in renal structure and function. These findings provide a baseline for understanding kidney health and disease.

Keywords:
3D dynamic contrast enhancementMR microscopyMRIcryogenic surface coilmouse kidney developmentradial keyhole imagingsmall-animal preclinical imaging

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Area of Science:

  • Biomedical Imaging
  • Renal Physiology
  • Developmental Biology

Background:

  • The kidney's critical functions make it susceptible to drug-induced toxicity and injury.
  • Early detection of renal toxicity and malformations requires effective methods to monitor kidney function.
  • Understanding normal kidney development is crucial for identifying deviations and diseases.

Purpose of the Study:

  • To develop and apply a high spatiotemporal resolution MRI method to track changes in kidney structure and function during normal development in mice.
  • To establish a foundational dataset for normal renal physiology.
  • To enable future studies on renal diseases requiring early detection.

Main Methods:

  • Acquisition of four-dimensional (4D) dynamic contrast-enhanced MRI (DCE-MRI) datasets in normal mice using keyhole imaging and a cryogenic surface coil.
  • Achieving high isotropic resolution (125 microns) with rapid 3D imaging (every 7.7 seconds) over a 50-minute scan.
  • Processing MRI data to segment four distinct kidney regions (cortex, outer stripe, inner stripe, inner medulla) and measuring local volumes, time-to-peak (TTP), and decay constants (DC) over a 17-week period.

Main Results:

  • Demonstrated successful visualization of contrast enhancement and clearance dynamics within the kidney over time.
  • Quantified age-dependent increases in local volumes and TTP values across renal regions.
  • Observed significant age-related changes in renal metrics, with notable exceptions in decay constants for specific outer medulla regions.

Conclusions:

  • The developed 4D DCE-MRI technique provides unprecedented insights into normal kidney development and function.
  • Age-related changes in renal structure and function were successfully characterized, establishing a normative dataset.
  • This foundational data is essential for future research into early detection and intervention strategies for renal diseases.