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Sexually transmitted pathogens in acute pelvic inflammatory disease
A A Hoosen1, D J Quinlan, J Moodley
1Department of Obstetrics and Gynaecology, University of Natal, Durban.
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|September 16, 1989
Summary
Pelvic inflammatory disease (PID) patients show a high prevalence of sexually transmitted infections, including Neisseria gonorrhoeae and Mycoplasma hominis. This highlights the need for antimicrobial agents effective against these pathogens in PID treatment.
Area of Science:
- Infectious Diseases
- Microbiology
- Women's Health
Background:
- Pelvic inflammatory disease (PID) is a significant cause of morbidity in women.
- Identifying the prevalence of specific sexually transmitted pathogens is crucial for effective treatment strategies.
Purpose of the Study:
- To determine the prevalence of various sexually transmitted pathogens in women with acute PID compared to asymptomatic women.
- To assess the need for specific antimicrobial agents in PID management based on pathogen prevalence.
Main Methods:
- Genital specimens were collected from 50 women with acute PID and 50 asymptomatic women attending a family planning clinic.
- Specimens were tested for Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma hominis, Trichomonas vaginalis, syphilis, and Hepatitis B surface antigen (HBsAg).
Main Results:
- Neisseria gonorrhoeae was found in 62% of PID patients vs. 10% of controls (P<0.0001), with one-third being penicillinase-producing strains.
- Mycoplasma hominis and Trichomonas vaginalis were significantly more prevalent in the PID group.
- Syphilis serology was positive in 34% of PID patients vs. 10% of controls (P=0.0026).
- Chlamydia trachomatis prevalence was similar between groups (30% vs. 26%, P=0.8240 NS).
- No HIV antibodies were detected in either group.
Conclusions:
- The high prevalence of Neisseria gonorrhoeae, Mycoplasma hominis, and Trichomonas vaginalis in PID patients underscores the need for effective antimicrobial treatment.
- Routine use of antibiotics active against penicillinase-producing Neisseria gonorrhoeae is recommended for PID management.