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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

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Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study

Pei-Chun Chan1, Chong-Hua Yu2, Kuo-Wei Yeh1

  • 1Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|July 29, 2014
PubMed

Insights

Pediatric patients with Systemic Lupus Erythematosus (SLE) face increased risks for infections, cardiovascular issues, and malignancies. This study highlights the importance of monitoring comorbidities in children diagnosed with SLE.

Area of Science:

  • Rheumatology
  • Pediatric Medicine
  • Epidemiology

Background:

  • Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease affecting multiple organs.
  • Pediatric SLE presents unique challenges in disease management and comorbidity surveillance.
  • Understanding comorbidity risks in pediatric SLE is crucial for long-term patient outcomes.

Purpose of the Study:

  • To investigate the spectrum and risks of comorbidities in children diagnosed with SLE.
  • To compare comorbidity frequencies in pediatric SLE patients versus the general pediatric population.
  • To provide a nationwide, population-based analysis of pediatric SLE comorbidities in Taiwan.

Main Methods:

  • Utilized the National Health Insurance Research Database (NHIRD) in Taiwan.
  • Included children under 18 years with ICD-9-CM code 710.0 for SLE diagnosis.
  • Analyzed comorbidities presenting after SLE diagnosis and compared frequencies with non-SLE controls.

Main Results:

  • 904 pediatric SLE patients (2003-2008) were analyzed.
  • Infection (86.36%) was the most frequent comorbidity, followed by musculoskeletal (16.7%) and cardiovascular (16.37%) diseases.
  • Pediatric SLE patients showed elevated risks for heart failure, hypertension, osteoporosis, cataracts, glaucoma, dyslipidemia, seizures, encephalopathy, and malignancy.

Conclusions:

  • Pediatric SLE patients in Taiwan exhibit a significant burden of systemic and chronic comorbidities.
  • Children with SLE have a demonstrably higher susceptibility to various diseases, including malignancies.
  • Findings underscore the need for proactive screening and management of comorbidities in pediatric SLE care.
Abstract

Keywords:
ComorbidityPediatricSystemic lupus erythematosusTaiwan

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