Setting the course for apoAII: a port in sight?

Area of Science:

• Biochemistry
• Lipid Metabolism
• Cardiovascular Research

Background:

• Apolipoprotein AII (ApoAII) is the second most abundant protein in human plasma High-Density Lipoproteins (HDLs).
• Nearly 2000 studies have investigated ApoAII's function in lipid metabolism over 50 years.
• ApoAII's role is contradictory, described as both pro- and anti-atherogenic, and as an activator/inhibitor of plasma activities.

Purpose of the Study:

• To summarize existing research on Apolipoprotein AII (ApoAII).
• To propose that ApoAII's influence on atherosclerosis can be shifted towards an antiatherogenic direction.
• To suggest strategies for maintaining this antiatherogenic course.

Main Methods:

• Review and synthesis of nearly 2000 existing studies.
• Analysis of epidemiological, cell-based, biochemical, and animal (mouse) and human data.
• Preponderance of evidence evaluation.

Main Results:

• ApoAII exhibits dual roles, acting as both a pro- and anti-atherogenic factor.
• The collective evidence supports the potential to modify ApoAII's function.
• ApoAII's influence can be directed towards mitigating atherosclerosis.

Conclusions:

• The complex role of ApoAII in lipid metabolism and atherosclerosis is acknowledged.
• ApoAII's trajectory can be steered towards an antiatherogenic outcome.
• Strategies exist to maintain ApoAII's beneficial, antiatherogenic effects.