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Lipid profile in children with coronary artery disease in Sindh, Pakistan

Saira Baloch1, Bikha Ram Devrajani1, Mohsin Ali Baloch1

  • 1Saira Baloch, Bikha Ram Devrajani, Medical Research Center, Liaquat University of Medical and Health Sciences, Sindh 75000, Pakistan.

World Journal of Cardiology
|July 29, 2014
PubMed

Insights

Children with coronary artery disease (CAD) exhibit abnormal lipid profiles, including higher total cholesterol and triglycerides and lower high-density lipoprotein. Genetic factors may contribute to childhood CAD development.

Area of Science:

  • Pediatric Cardiology
  • Biochemistry
  • Genetics

Background:

  • Coronary artery disease (CAD) in children is a growing concern.
  • Understanding lipid profiles in affected children is crucial for early risk assessment.
  • Genetic predisposition is increasingly recognized in early-onset cardiovascular conditions.

Purpose of the Study:

  • To investigate the lipid profiles of children diagnosed with coronary artery disease (CAD).
  • To compare lipid parameters between children with and without a family history of CAD.
  • To explore potential genetic influences on childhood CAD in Hyderabad, Sindh, Pakistan.

Main Methods:

  • A cohort of 100 children aged 6-15 years was studied.
  • 43 children had a parental history of CAD (cases), and 57 served as controls.
  • Fasting blood lipid profiles were analyzed using a kit method on Microlab 300.

Main Results:

  • Children with CAD showed significantly elevated total serum cholesterol and triglycerides.
  • Decreased levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were observed in children with CAD.
  • Systolic and diastolic blood pressures were significantly higher in the CAD group.

Conclusions:

  • Abnormal lipid levels are significant risk factors for CAD in children.
  • A genetic tendency appears to play a crucial role in the development of childhood CAD.
  • Early identification of lipid abnormalities and genetic predispositions is vital for pediatric cardiovascular health.
Abstract

Keywords:
ChildrenCoronary artery diseaseLipid profileSerumSindh

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