Related Experiment Video
Updated: Apr 26, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
Published on: April 28, 2022
Updated international clinical recommendations on scar management: part 1--evaluating the evidence
Michael H Gold1, Brian Berman, Matteo Tretti Clementoni
1*Gold Skin Care Center and Tennessee Clinical Research Center, Nashville, Tennessee; †Center for Clinical and Cosmetic Research, Aventura, Florida; ‡Department of Laser and Surgery, Istituto Dermatologico Europeo, Milano, Italy; §Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany; ‖Paces Plastic Surgery, Atlanta, Georgia; ¶Inkwell Medical Communications, Novelty, Ohio.
Background:
There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice.
Objective:
To review available data on methods for preventing and treating cutaneous scarring.
Materials And Methods:
Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management.
Results:
One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment.
Conclusion:
Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
Related Concept Videos
Healing II: Complications
Clinical Applications of Epidermal Stem Cells
Acne Infection
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Varicose Veins II: Diagnostic Studies and Interprofessional Care

