Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomonitoring Equivalents for select neonicotinoids.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors.

Critical reviews in toxicology·2026
Same author

Biomonitoring Equivalents for interpreting mandelic and phenylglyoxylic acid in urine resulting from exposures to styrene and ethylbenzene.

Regulatory toxicology and pharmacology : RTP·2026
Same author

PFOS and PFOA exposure induces liver injury and sex-dependent immune effects in C57BL/6 mice.

iScience·2026
Same author

The Creation of a Weight of Evidence Scoring Database for Risk Factors for Adverse Impacts to Birth Outcomes Using Expert Elicitation.

Birth defects research·2026
Same author

Improving the design of epidemiology studies that use biomonitoring for exposure assessment: a SciPinion panel recommendation.

BMC medical research methodology·2026

Related Experiment Video

Updated: Apr 26, 2026

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
08:00

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays

Published on: December 4, 2016

6.8K

Biomonitoring Equivalents for selenium.

Sean M Hays1, Kristin Macey2, Andy Nong2

  • 1Summit Toxicology, LLP, Allenspark, CO, USA.

Regulatory Toxicology and Pharmacology : RTP
|July 29, 2014
PubMed
Summary

Selenium is vital but toxic in excess. Biomonitoring Equivalents (BEs) for selenium in blood, plasma, and urine help assess intake adequacy and prevent toxicity, aiding public health risk assessment.

Keywords:
BiomonitoringBiomonitoring EquivalentsRisk assessmentSelenium

More Related Videos

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

11.7K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

1.0K

Related Experiment Videos

Last Updated: Apr 26, 2026

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
08:00

Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays

Published on: December 4, 2016

6.8K
An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium
09:33

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

11.7K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

1.0K

Area of Science:

  • Nutritional biochemistry
  • Toxicology
  • Public health

Background:

  • Selenium is an essential trace element with a narrow therapeutic window, crucial for protein function.
  • Deficiency causes Keshan disease; excess leads to selenosis (hair/nail issues, GI distress).
  • Dietary Reference Intakes (DRIs) and guidance values exist, but monitoring intake is challenging.

Purpose of the Study:

  • To establish Biomonitoring Equivalents (BEs) for selenium.
  • To provide reference values for interpreting biomonitoring data for both nutritional adequacy and toxicity.
  • To aid regulatory agencies and public health officials in risk assessment.

Main Methods:

  • Development of Biomonitoring Equivalents (BEs) for selenium.
  • Defined BEs based on Estimated Average Requirements (EAR) for adequacy.
  • Defined BEs based on guidance values for preventing selenosis.

Main Results:

  • Established selenium BEs for whole blood (100 μg/L for EAR, 400-480 μg/L for toxicity).
  • Established selenium BEs for plasma (80 μg/L for EAR, 180-230 μg/L for toxicity).
  • Established selenium BEs for urine (10 μg/L for EAR, 90-110 μg/L for toxicity).

Conclusions:

  • BEs provide a framework for interpreting selenium biomonitoring data.
  • These values facilitate assessment of selenium status relative to health guidance.
  • BEs support public health initiatives for managing selenium exposure risks.