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Updated: Apr 26, 2026

A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue
Umar Alqasemi1, Hai Li2, Guangqian Yuan3
1King Abdulaziz University, Department of Electrical and Computer Engineering, PO Box 80204, Jeddah 21589, Saudi ArabiabUniversity of Connecticut, Department of Biomedical Engineering, 371 Fairfield Way; U-4157, Storrs, Connecticut 06269-4157, United State.
Abstract:
Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.
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