[Relationship between gene p53 codon 72 polymorphism and pathological scar formation after caesarean section]

Area of Science:

• Genetics
• Obstetrics and Gynecology
• Dermatology

Background:

• Pathological scarring after caesarean section is a common concern.
• The role of genetic factors in scar formation requires further investigation.

Purpose of the Study:

• To investigate the association between p53 gene codon 72 polymorphism and the occurrence of pathological scars following caesarean section.

Main Methods:

• Real-time PCR with molecular beacon technology was used to genotype the p53 codon 72 polymorphism in 303 women post-caesarean section.
• Clinical assessments over 12-18 months identified pathological scar formation.
• Chi-square analysis was employed to determine statistical significance.

Main Results:

• The C/C genotype and C allele of p53 gene codon 72 were significantly more frequent in women with pathological scars compared to those without.
• The C allele was identified as a risk factor for pathological scar formation (OR = 2.30).

Conclusions:

• A significant association exists between the p53 gene codon 72 C allele and the development of pathological scars after caesarean section.
• The p53 gene codon 72 C allele may serve as a predictive marker for pathological scar formation.