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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
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Investigating human disease using stem cell models.

Jared L Sterneckert1, Peter Reinhardt1, Hans R Schöler1

  • 1Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany.

Nature Reviews. Genetics
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Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) are crucial for creating accurate human disease models and advancing drug development. Combining iPSCs with gene editing offers powerful tools for studying complex genetic disorders.

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Area of Science:

  • Stem cell biology
  • Disease modeling
  • Genetic engineering

Background:

  • Accurate disease models are vital for understanding pathogenesis and developing therapeutics.
  • Stem cells offer self-renewal and differentiation capabilities, ideal for disease modeling and cell production.
  • Previous models used adult and embryonic stem cells, but induced pluripotent stem cells (iPSCs) show greater utility.

Purpose of the Study:

  • To highlight the utility of induced pluripotent stem cells (iPSCs) in disease modeling.
  • To emphasize the potential of combining iPSCs with gene editing for complex genetic disorders.

Main Methods:

  • Utilizing stem cell properties for disease modeling.
  • Employing induced pluripotent stem cells (iPSCs) for human disease research.
  • Integrating gene editing technologies with iPSCs.

Main Results:

  • Induced pluripotent stem cells (iPSCs) demonstrate significant utility in modeling human diseases.
  • Combining gene editing with iPSCs enables the creation of models for genetically complex disorders.

Conclusions:

  • Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling and drug development.
  • Gene editing combined with iPSCs offers a promising approach for studying complex genetic diseases.