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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Related Experiment Video

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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Male osteoporosis.

A Giusti1, G Bianchi

  • 1Bone Clinic, Department of Gerontology and Musculoskeletal Sciences, Galliera Hospital, Genova. gerolamo_bianchi@tin.it.

Reumatismo
|July 30, 2014
PubMed
Summary

Osteoporotic fractures are a growing global health issue. This review summarizes recent research on male osteoporosis, covering causes, risk factors, and treatments to improve bone health.

Area of Science:

  • Gerontology
  • Orthopedics
  • Endocrinology

Background:

  • Osteoporotic fractures pose a significant global health burden due to population aging.
  • Male osteoporosis, while less common than in women, is an underrecognized condition contributing to morbidity, mortality, and economic costs.
  • Recent decades have seen increased research into male osteoporosis's pathogenesis, diagnosis, and treatment.

Purpose of the Study:

  • To review recent findings on male osteoporosis.
  • To focus on risk factors, causes of bone loss, and therapeutic strategies.
  • To provide an overview of current understanding and management of male osteoporosis.

Main Methods:

  • Literature review of recent studies on male osteoporosis.
  • Synthesis of information on risk factors and bone loss mechanisms.

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  • Analysis of current and emerging therapeutic options.

    • Main Results:

    • Understanding of male osteoporosis pathogenesis has advanced significantly.
    • Screening and diagnostic strategies have been refined.
    • Therapeutic interventions show potential for improving bone mineral density and reducing fracture risk in men.

    Conclusions:

    • Male osteoporosis is a serious medical condition requiring attention.
    • Improved diagnostic and therapeutic approaches are enhancing patient outcomes.
    • Further research continues to refine the management of bone fragility in men.