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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

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Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Related Experiment Video

Updated: Apr 26, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Benign bone tumors.

Robert Steffner1

  • 1Orthopaedic Oncology, UC Davis Comprehensive Cancer Center, Sacramento, CA, USA, robert.steffner@ucdmc.ucdavis.edu.

Cancer Treatment and Research
|July 30, 2014
PubMed
Summary

This chapter reviews common benign bone tumors, detailing their presentation, imaging, and diagnostic features. It aims to guide clinicians in managing these diverse bone lesions effectively.

Area of Science:

  • Orthopedic Oncology
  • Radiology
  • Pathology

Background:

  • Benign bone lesions encompass a wide range of conditions with varying clinical behaviors.
  • Accurate differentiation of these tumors is crucial for appropriate patient management and intervention.
  • Understanding the spectrum of benign bone tumors aids in clinical decision-making.

Purpose of the Study:

  • To provide a comprehensive overview of common benign bone tumors.
  • To detail the presentation, imaging characteristics, and diagnostic features of these lesions.
  • To guide the diagnosis and management of benign bone tumors.

Main Methods:

  • Review of literature on common benign bone tumors.
  • Analysis of diagnostic features and imaging modalities.

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  • Discussion of treatment strategies for benign bone lesions.

    • Main Results:

    • Detailed description of the clinical presentation of various benign bone tumors.
    • Explanation of key imaging findings (radiography, MRI, CT) for differential diagnosis.
    • Outline of diagnostic criteria and pathological features.

    Conclusions:

    • Effective differentiation of benign bone tumors is essential for appropriate treatment.
    • Multimodal diagnostic approaches are key to accurate tumor characterization.
    • This chapter serves as a resource for clinicians managing benign bone pathology.