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Updated: Apr 26, 2026
Maturation of Human Stem Cell-derived Cardiomyocytes in Biowires Using Electrical Stimulation
Published on: May 6, 2017
Design and fabrication of biological wires
Jason W Miklas1, Sara S Nunes, Boyang Zhang
1Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Room 407, Toronto, ON, Canada, M5S 3G9.
Abstract:
Cardiac tissue engineering using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has facilitated the creation of in vitro diagnostic platforms to study novel small molecules and cardiac disease at the tissue level. Yet, due to the immaturity of hPSC-CMs, there is a low fidelity between tissue-engineered cardiac tissues and adult cardiac tissues. To address this challenge, we have developed a platform that combines both physical and electrical cues to guide hPSC-CMs towards a more mature state in vitro.
