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[Central blood pressure and vascular damage]

Francisco Pérez-Lahiguera1, Enrique Rodilla2, José Antonio Costa1

  • 1Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital de Sagunto, Agencia Valenciana de Salud, Sagunto, Valencia, España.

Medicina Clinica
|July 30, 2014
PubMed

Insights

Central blood pressure (CBP) showed no superior correlation with vascular organ damage (VOD) compared to peripheral blood pressure. Twenty-four-hour blood pressure (BP24h) emerged as the strongest predictor of VOD.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Hypertension is a major risk factor for vascular organ damage (VOD).
  • Assessing the relationship between different blood pressure (BP) measurements and VOD is crucial for risk stratification.
  • Central blood pressure (CBP) is proposed as a better indicator of cardiovascular risk than peripheral BP.

Purpose of the Study:

  • To evaluate the association between central blood pressure (CBP) and vascular organ damage (VOD).
  • To compare the predictive value of CBP, clinical BP, and 24-hour ambulatory BP (BP24h) for VOD.

Main Methods:

  • Cross-sectional study of 393 never-treated hypertensive patients.
  • Measurements included clinical BP, 24-hour ambulatory BP (BP24h), and central BP (CBP).
  • Vascular organ damage (VOD) assessed via albumin/creatinine ratio (ACR), pulse pressure velocity, and left ventricular mass index (LVMI).

Main Results:

  • Patients with VOD exhibited higher BP, BP24h, and CBP values.
  • Systolic BP24h demonstrated a stronger linear correlation with CBP and LVMI than peripheral BP.
  • In multivariate analysis, systolic BP24h was the strongest predictor of VOD (OR: 3.4).

Conclusions:

  • Central blood pressure (CBP) does not show a stronger correlation with vascular organ damage (VOD) than peripheral BP measurements.
  • Twenty-four-hour ambulatory blood pressure (BP24h) is the most effective BP measurement for predicting VOD in hypertensive patients.
Abstract

Keywords:
24-hours blood pressureCentral blood pressureDaño vascularPresión arterial centralPresión arterial de 24 horasVascular organ damage

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