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Updated: Apr 26, 2026
In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules
Published on: August 22, 2016
Ferritins as nanoplatforms for imaging and drug delivery
Zipeng Zhen1, Wei Tang, Trever Todd
1University of Georgia, Department of Chemistry , Athens, GA 30602 , USA.
Introduction:
Due to unique architecture and surface properties, ferritin has emerged as an important class of biomaterial. Many studies suggest that ferritin and its derivatives hold great potential in a wide range of bio-applications.
Areas Covered:
In this review, we summarize recent progress on employing ferritins as a platform to construct functional nanoparticles for applications in MRI, optical imaging, cell tracking, and drug delivery.
Expert Opinion:
As a natural polymer, ferritins afford advantages such as high biocompatibility, good biodegradability, and a relatively long plasma half-life. These attributes put ferritins ahead of conventional materials in clinical translation for imaging and drug delivery purposes.
