[Effect of bromocriptine and bromocriptine combined with prolactin on the proliferation of thymocytes in young rats]
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T Aboussaouira1, C Marie, S Idelman
1Equipe Hormones et Immunité, Université Joseph-Fourier, Grenoble.
Abstract:
The effects of bromocriptine and bromocriptine associated to prolactin have been investigated on young rat thymocytes after sensitization with T-cell antigen SRBC using a quantitative nucleus image analysis (Samba 200). Bromocriptine alone induces an inhibition of lymphocyte proliferation, a chromatin condensation and enhances cell differentiation. These effects are reversed by prolactin, which therefore acts on lymphocytes before they leave the thymus.