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The correlation between renal function and bone mineral density
T -H Tseng1, C -F Mu, C -Y Hsu
1Department of Orthopedics National Taiwan University Hospital Taipei, Taiwan - 4211@mail.pch.org.tw.
Insights
Bone mineral density (BMD) significantly decreases in men with mild chronic kidney disease (CKD). Osteoporosis screening is recommended for patients with reduced kidney function, especially women in advanced CKD stages.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- Chronic kidney disease (CKD) is linked to bone loss, particularly in moderate to end-stage renal disease.
- The impact of mild CKD on bone mineral density (BMD) remains unclear.
- Investigating the association between reduced glomerular filtration rate (GFR) and BMD is crucial.
Purpose of the Study:
- To determine if reduced GFR in mild and severe chronic kidney disease (CKD) is associated with decreased bone mineral density (BMD).
- To analyze BMD variations across different stages of CKD.
Main Methods:
- 305 patients were categorized into CKD stages I, II, and ≥III based on estimated GFR calculated using the CKD-EPI equation.
- BMD was compared between these CKD stage groups.
- Data collected between April and November 2011.
Main Results:
- Significant bone loss was observed in CKD stage ≥III, particularly in women (P<0.05).
- Male participants with CKD stage II demonstrated a significant decrease in BMD (P=0.041).
- The study included 81 women and 65 men with an average age of 65.6.
Conclusions:
- Mild renal dysfunction is associated with significantly decreased BMD in men.
- Advanced CKD stages (≥III) also show significant BMD reduction, especially in women.
- Routine osteoporosis screening is advisable for individuals with impaired kidney function.
Aim:
The moderate, severe chronic kidney disease (CKD) and end stage renal disease (ESRD) are well-recognized risk factors of bone loss. However, it is uncertain whether mild CKD stage affects bone mineral density (BMD). The objective of this study is to investigate whether mild and/or more severe reduction of GFR is associated with BMD decreasing.
Methods:
Between April and November 2011, 305 patients were included in this study. Estimated glomerular filtration rate (GFR) was calculated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. According to the GFR, we divided the participants into 3 groups: CKD stage I, stage II and stage ≥III. BMD was compared between different groups.
Results:
Eighty-one women and 65 men were enrolled in the final study. The average age was 65.6. According to the eGFR, 54 (37.0%), 70 (47.9%) and 22 (15.1%) participants were classified into CKD stage I, II and ≥III, respectively. The mean T-score was -1.351±1.879.A significant bone loss was found in the stage ≥III group, especially in women (P<0.05). BMD decreasing was found significantly in male participants with CKD stage II (P=0.041).
Conclusion:
BMD significantly decreased in men with mild renal dysfunction. A significant BMD decreasing was also found in the group of CKD stage ≥III, especially in women. We suggest osteoporosis screening is necessary in patients with poor renal function.
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