The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers

Area of Science:

• Biogerontology
• Biotechnology
• Longevity Science

Background:

• The concept of eradicating age-related degeneration through physical repair is a prominent area of research.
• However, this approach faces significant challenges due to numerous unknown variables.

Purpose of the Study:

• To critically evaluate the feasibility of physical interventions for aging.
• To explore the potential limitations of developing and implementing rejuvenation biotechnologies.

Main Methods:

• Discussion of specific examples: cross-link breakers, lysosomal degradation therapy, and whole-body interdiction of lengthening of telomeres (WILT).
• Analysis of theoretical biotechnological advancements versus practical human application.

Main Results:

• The search for effective cross-link breakers and lysosomal degradation therapies presents research challenges.
• Whole-body interdiction of lengthening of telomeres (WILT) is a more speculative strategy.
• Even if developed, these therapies may be unusable by the general public.

Conclusions:

• Physical interventions alone are insufficient to cure aging.
• Biological, evolutionary, and psychological factors limit the practical application of rejuvenation biotechnologies.
• A comprehensive approach beyond physical repair is necessary to address aging.