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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Microbial biosynthesis of medicinally important plant secondary metabolites
Myoung Chong Song1, Eun Ji Kim, Eunji Kim
1Department of Chemistry and Nano Science, Ewha Global Top 5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea. joonyoon@ewha.ac.kr.
Abstract:
Secondary metabolites derived from plants are a valuable source of pharmaceuticals, nutraceuticals, and cosmetics. To harness the potential of these natural products, reliable methods must be developed for their rapid and sustainable resupply. Microbial production of plant secondary metabolites through the heterologous expression of plant biosynthetic genes represents one such solution. This highlight focuses on recent advances in the microbial biosynthesis of plant secondary metabolites including terpenoids, flavonoids, and alkaloids as well as providing a brief insight into the current limitations and future prospects.
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