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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Elastoderma: Case Report and Literature Review.

Hala Adil1, Sarah Walsh

  • 1*Department of Dermatology, Saint Louis University, St. Louis, MO; and †Cutaneous Pathology, WCP Laboratories, Inc, St. Louis, MO.

The American Journal of Dermatopathology
|July 30, 2014
PubMed
Summary
This summary is machine-generated.

Elastoderma is a rare skin condition causing acquired skin laxity and decreased recoil. Histology shows increased, fragmented elastic fibers in the dermis, as seen in this fifth reported case.

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Area of Science:

  • Dermatology
  • Cutaneous Medicine
  • Histopathology

Background:

  • Elastoderma is a rare cutaneous condition characterized by acquired skin laxity and decreased recoil.
  • Histological findings include an increase of pleomorphic and fragmented elastic fibers in the superficial dermis.

Observation:

  • A case report details a 61-year-old woman presenting with wrinkled, lax skin on the anterior and lateral neck.
  • Clinical presentation suggests acquired dermal changes affecting skin elasticity.

Findings:

  • Microscopic examination confirmed an accumulation of fragmented, curled elastic fibers within the dermis.
  • The histological findings are consistent with the diagnosis of elastoderma.

Implications:

  • This case represents the fifth documented instance of elastoderma, contributing to the limited existing literature.
  • Further research into the pathogenesis and potential treatments for elastoderma is warranted.