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Updated: Apr 26, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
Guanidyl-functionalized graphene as a bifunctional adsorbent for selective enrichment of phosphopeptides
Lin-Nan Xu1, Li-Ping Li, Liang Jin
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Institute of Analytical Chemistry, Peking University, Beijing 100871, China. yu.bai@pku.edu.cn.
Abstract:
Guanidyl-functionalized graphene (GFG) was designed and synthesized. By simple modulation of the loading buffer this novel bifunctional adsorbent provides two enriching functions, one for global phosphopeptides, and the other for multiphosphopeptides with consecutive phosphorylated residues. GFG provides a promising perspective for consecutive phosphorylated peptide enrichment in phosphor-proteomic research and related biological process studies.
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