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Cloning, sequence analysis and chromosome localization of a Drosophila muscarinic acetylcholine receptor
T Onai1, M G FitzGerald, S Arakawa
1Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
FEBS Letters
|September 25, 1989
Abstract:
Two cDNA clones (3.7 kb and 4.8 kb) encoding a Drosophila muscarinic acetylcholine receptor were isolated from a Drosophila head cDNA library and characterized by automated DNA sequence analysis. The Drosophila muscarinic receptor contains 788 amino acids with a calculated Mr of 84,807 and displays greater than 60% homology with mammalian muscarinic receptors. The muscarinic receptor maps to the tip of the right arm of the second chromosome of the Drosophila genome.