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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
Advances in clinical cardiology
Andrew H McNeice1, Neil M McAleavey, Ian B A Menown
1Craigavon Cardiac Centre, Southern Trust, Northern Ireland, BT63 5QQ, UK.
Insights
This review covers recent cardiology trials, focusing on acute coronary syndromes, interventions, and bypass surgery. It also discusses new findings in heart failure, atrial fibrillation, cardiac arrest, and cardiovascular prevention.
Area of Science:
- Cardiology
- Clinical Trials
- Cardiovascular Medicine
Background:
- Numerous significant cardiology trials have been published recently.
- These trials impact clinical practice across various cardiovascular conditions.
Purpose of the Study:
- To summarize and contextualize new data from recent cardiology trials.
- To provide an overview of advancements in cardiovascular disease management and treatment.
Main Methods:
- Review of recently presented and published cardiology trial data.
- Synthesis of information on acute coronary syndromes, interventions, bypass surgery, heart failure, arrhythmias, cardiac arrest, and prevention.
Main Results:
- New insights into acute coronary syndrome management including copeptin assessment and various pharmacotherapies.
- Updated data on coronary interventions, including thrombectomy, access methods, fractional flow reserve, and antiplatelet strategies.
- Recent findings on trans-aortic valve implantation, heart failure therapies, atrial fibrillation management, cardiac arrest interventions, and cardiovascular prevention strategies.
Conclusions:
- The latest trial data offers practice-changing updates across a broad spectrum of cardiovascular medicine.
- Clinicians must stay abreast of these advancements to optimize patient care in cardiology.
Abstract:
Multiple, potentially practice-changing cardiology trials have been presented or published over the past year. In this paper, we summarize and place in clinical context, new data regarding management of acute coronary syndrome and ST-elevation myocardial infarction (copeptin assessment, otamixaban, cangrelor, prasugrel, sodium nitrite, inclacumab, ranolazine, preventive coronary intervention of non-culprit lesions, immediate thrombolytic therapy versus transfer for primary intervention), new coronary intervention data (thrombectomy, radial access, pressure wire fractional flow reserve, antiplatelet therapy duration and gene-guidance, permanent and biodegradable polymers, coronary bifurcation and strategies), and coronary artery bypass data (off pump vs. on pump). Latest trials in trans-aortic valve implantation, heart failure (eplerenone, aliskiren, spironolactone, sildenafil, dopamine, nesiritide, omecamtiv mecarbil, the algisyl left ventricular augmentation device, and echo-guided cardiac resynchronization), atrial fibrillation (edoxaban, dabigatran, and ablation), cardiac arrest (hypothermia, LUCAS™ mechanical chest compression), and cardiovascular prevention (vitamins, renal denervation for resistant hypertension, renal artery stenting, saxagliptin, alogliptin, and gastric banding) are also discussed.
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