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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Newly identified pathogens associated with periodontitis: a systematic review
P J Pérez-Chaparro1, C Gonçalves1, L C Figueiredo1
1Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, Brazil.
Journal of Dental Research
|July 31, 2014
Summary
This systematic review found moderate evidence linking 17 new bacterial species to periodontitis. These findings highlight previously unidentified microorganisms
Area of Science:
- Periodontology
- Microbiology
- Oral Health Research
Background:
- Established evidence links specific oral bacteria to periodontitis.
- Recent diagnostic methods suggest novel periodontal pathogens.
- Previous studies on new pathogens lacked consolidated evaluation.
Purpose of the Study:
- To systematically review and assess the evidence for newly identified periodontal pathogens.
- To evaluate the association of these microorganisms with periodontitis based on existing studies.
Main Methods:
- Systematic review adhering to the PRISMA statement.
- Searched MEDLINE, EMBASE, and Cochrane databases up to September 2013.
- Included 41 studies comparing subgingival plaque microbial data from periodontitis patients and healthy individuals, focusing on non-established pathogens.
Main Results:
- Moderate evidence supports the association of 17 species/phylotypes with periodontitis.
- Involved phyla include Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes.
- Candidatus Saccharibacteria and Archaea also show potential disease association.
Conclusions:
- Previously unrecognized species play a significant role in periodontitis etiology.
- These findings underscore the importance of novel pathogens in periodontitis.
- Future research should focus on the precise role of these suspected pathogens in disease onset and progression.
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