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Updated: Apr 26, 2026

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
SOX18 expression predicts response to platinum-based chemotherapy in ovarian cancer
Bartosz Pula1, Christopher Kobierzycki2, Daniel Solinski2
1Department of Histology and Embryology, Medical University in Wroclaw, Wroclaw, Poland bartosz.pula@umed.wroc.pl.
Background:
SOX18 is a transcription factor known to be involved in blood and lymphatic vessel, hair follicle development, and wound healing processes. In addition, it has been reported that SOX18 may influence cancer growth. The role of SOX18 expression in ovarian cancer (OC) has not been determined.
Materials And Methods:
SOX18 expression was assessed in 85 OC cases using immunohistochemical methods and in ovarian cancer cell lines on the mRNA and protein level.
Results:
SOX18 was expressed in cancer cell nuclei as well as the cytoplasm. Higher nuclear SOX18 expression was associated with presence of residual disease following surgical treatment (p=0.0158) and advanced disease stage (p=0.0056). Univariate survival analysis revealed that high SOX18 (p=0.0125) expression, presence of residual disease (p<0.0001) and advanced disease stage (p<0.0324) predicted poor patient outcome.
Conclusion:
SOX18 may be a new predictive marker for OC.
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