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Macroscopic type is a prognostic factor for recurrence-free survival after resection of gastric GIST
Hiroshi Miyamoto1, Chikara Kunisaki2, Yuichi Otsuka3
1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan yo-chan.634@nifty.com.
Background:
Accurate evaluation of the biological behavior of Gastrointestinal stromal tumor and careful selection of patients with a high risk for tumor recurrence are necessary. In the present study, we analyzed prognostic factors in patients with GIST.
Patients And Methods:
A total of 214 patients who had undergone curative resection of a localized primary gastric GIST without adjuvant therapy were enrolled in this retrospective study. Prognostic factors were analyzed. The growth pattern was classified as intramural, endoluminal, exoluminal, or mixed- type.
Results:
On univariate and multivariate analyses, recurrence was predicted by exoluminal or mixed-type (hazard ratio [HR]=3.7, p=0.043), tumor size of >3.5 cm (HR=7.1, p=0.01), and mitotic rate of >5/50 high-power fields (HR=7.9, p<0.001).
Conclusion:
It is suggested that exoluminal or mixed-type is independently associated with recurrence of surgically resected gastric GIST in addition to tumor size and mitotic rate.
