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Clinical translation in the virtual liver network
L Kuepfer1, R Kerb2, A M Henney3
1Bayer Technology Services GmbH, Computational Systems Biology, Leverkusen, Germany.
Abstract:
The liver is the central detoxifying organ, continuously removing xenobiotics from the vascular system. Given its role in drug metabolism, a functional understanding of liver physiology is crucial to optimizing drug efficacy and patient safety. The Virtual Liver Network (VLN), a German national flagship research program, focuses on producing validated computer models of human liver physiology. These models are used to analyze patient-derived data and thereby gain mechanistic insights in the processes underlying drug pharmacokinetics (PK).
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